Main sample data were analysed as aggregated values and by country (France, Germany, Italy, Spain, UK). Accessed 21 Feb 2023. The majority (~80%) of patients with PD-L1 expression of50% were receiving 1L IO, which was used across all histological types investigated (squamous cell carcinoma, adenocarcinoma, large cell carcinoma). Physicians completed record forms (RFs) for the next six consecutive consulting patients with advanced NSCLC, who then voluntarily completed questionnaires. Copyright 2023 Dana-Farber Cancer Institute As patients consult at random, the patient sampling method is considered to generate a patient sample representative of the typical mNSCLC consulting population. We care for adults and children with cancer in our specialized treatment centers, focused on specific cancer types. Real-world physician and patient behaviour across countries: Disease-Specific Programmes - a means to understand. How the Shortage of a $15 Cancer Drug Is Upending Treatment 2003;170(3):125766. Steffen McLouth LE, Lycan TW Jr, Levine BJ, Gabbard J, Ruiz J, Farris M, et al. Specialties. The retrospective oversample analysis was based around the emergence of COVID-19 in Europe and examined effects of the virus and lockdown on the treatment and management of mNSCLC. PubMedGoogle Scholar. At the time of data collection, patients mean age (SD) was 66.2 (8.9) years and 65.1% were male. Tong X, Tanino R, Sun R, Tsubata Y, Okimoto T, Takechi M, Isobe T. Protein tyrosine kinase 2: a novel therapeutic target to overcome acquired EGFR-TKI resistance in non-small cell lung cancer. Doctors at Memorial Sloan Kettering Cancer Center (MSK) pioneered advances in many types of cancer treatment for patients in 2022. Evidence for validity of a national physician and patient-reported, cross-sectional survey in China and UK: the Disease Specific Programme. Top Cancer Treatment Advances at MSK in 2022 2020;9:254556. Programmed Death Ligand-1 Immunohistochemistry: Friend or Foe? Google Scholar. Patient-reported EQ-5D VAS, EQ-5D utility index, and FACT are reported in Table 7. To KKW, Fong W, Cho WCS. Bailey, H., Lee, A., Eccles, L. et al. There was a difference between groups in comorbid hypertension (p=0.0047), chronic pulmonary disease (p=0.007), and diabetes without chronic complications (p=0.0024); current Charlson comorbidity index was0.8 for most treatment groups and 1.9 for the other patient group (p<0.0001 all treatment groups). Five years after prostate cancer diagnosis, 93.2% of the patients in Finland are alive. Aspartame sweetener to be declared possible cancer risk by WHO, say The overall relative 5-year survival rate for lung cancer is 23%, although this varies depending on clinical stage, and is 61% for localised, 34% for regional, and 7% for metastatic disease [5]. Lung Cancer Non-small cell: Statistics. No response was reported for twice as many patients with PD-L1 expression of<1% (31.7%) versus 149% (16.0%) and50% (16.7%). Eur J Cancer. Specialty. Physicians meeting the inclusion criteria and willing to participate first completed an attitudinal survey regarding the management and treatment of patients with mNSCLC. The patient-reported questionnaire collected data on patient demographics, disease burden, and quality of life (QoL). Summary of the HIPAA Privacy Rule; 2003. This analysis of the characteristics and the current diagnostic landscape in patients with EGFR-WT/ALK-WT mNSCLC across Europe found that IO as well as chemotherapy-based regimens were frequently prescribed as 1L treatment. Chest. We understand that cancer affects patients and their families in many ways. Dana-Farber Cancer Institute remains true to Dr. Sidney Farber's vision of a cancer center that is as dedicated to discoveries in cancer research as it is to delivering compassionate, patient-centered care. Chemotherapy. Article They also represent a pragmatic sample that may not be representative of the overall population of physicians treating NSCLC. Mean EQ-5D-5L utility scores ranged from 0.77 (0.29) for France to 0.90 (0.12) for UK. Your US state privacy rights, In Europe alone, the prevalence, incidence, and death rates in 2020 were 22.4%, 21.6% and 21.4%, respectively [1]. The Catholic University Of Korea - Seoul St. Mary's Hospital. 2007;5:70. International Society for Pharmacoeconomics and Outcomes Research (ISPOR). CAS Drugs approved a decade ago can cure hepatitis C, but most infected Article The FACT-G is designed to measure the physical, social, emotional, and functional well-being domains of QoL in patients with cancer [24, 31]. 1). 7 new breakthroughs in the fight against cancer - The World Economic Forum Patients in Germany appeared to be overall least impacted by the pandemic with regards to their mNSCLC treatment and management, particularly with minimal change in method of consultation and few treatment changes. Williams Cancer Institute | LinkedIn https://doi.org/10.1016/S1470-2045(17)30690-3. Stage 1 prostate cancer is the least advanced stage. 2017. https://www.ispor.org/docs/default-source/presentations/1066.pdfI Accessed 21 Feb 2023. After decades of limited success, scientists say research has reached a turning point, with many predicting more vaccines . India provides world-class cancer treatment at much lower costs when compared with other countries. Data were summarized using descriptive analyses. Lung cancer is the leading cause of cancer deaths globally, accounting for 18% (1.8 million) of deaths and 11.4% (2.2 million) of new cases in 2020 [1, 2]. Privacy Moreover, the disruption from COVID-19 exposure and resource reallocation, as a result of the pandemic, have led to the development of new recommendations to replace current guidelines for clinicians managing patients with lung cancer such as delays in evaluation and treatment in specific cases [45]. Google Scholar. Breast cancer, lung cancer and colon cancer are among the most common cancers. 11 alternative cancer treatments to consider - Mayo Clinic Stage 1 treatment options. The EQ-5D-5L French value set was used for all countries to remove bias in cross-country comparisons due to country differences in value sets [25]. EuroQola new facility for the measurement of health-related quality of life. KINDLE-Asia, as part of a real world global study, evaluated treatment patterns and associated survival outcomes in stage III NSCLC in Asia.MethodsRetrospective data from 57 centers in patients with stage III NSCLC diagnosed between January 2013 and December 2017 were . For the total population of patients with EGFR-WT/ALK-WT mNSCLC (n=2373), a reduction in frequency of consultation was reported for 14.9% (range: 8.1% in France to 22.2% in the UK). 1990;16:199208. EuroQol Research Foundation. https://euroqol.org/publications/user-guides/. 6 experts reveal the technologies set to revolutionize cancer care Technology in cancer care: Low-dose CT cancer screening programmes can help reduce mortality rates. Physician and patient data were pseudo-anonymized. Advanced Cancer Treatment Options Figure 4. Lung. Data were drawn from the Adelphi NSCLC Disease Specific Programme, a point-in-time survey of oncologists/pulmonologists and their consulting patients in France, Germany, Italy, Spain and UK. Google Scholar. Health Information Technology Act. Front Immunol. The DSP methodology has been previously published and validated [17,18,19,20], with studies across many different disease areas implemented globally. Quality of life (QoL) reported by patients was generally lower than normative reference values. Upon receipt by Adelphi Real World, data were pseudo-anonymized again to mitigate against tracing them back to the individual. Int J Cancer. Patient characteristics for the EGFR-WT/ALK-WT mNSCLC population split by the period in which patients were diagnosed (pre-COVID-19 and during COVID-19) are shown in Table 8. Most NSCLC tumours in Europe lack oncogenic driver mutations, rendering patients without targetable mutations ineligible to receive targeted therapies [7]. Geneva, Switzerland: WHO (2022). Global comparison of cancer outcomes: standardization and correlation QoL was measured using the EQ-5D-5L [21, 22], and the Functional Assessment of Cancer Therapy (FACT), including the FACT-General (FACT-G) and FACT-Lung (FACT-L) [23, 24]. Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020 (1). Available from: https://www.ncbi.nlm.nih.gov/books/NBK500364/. For the oversample, oncologists/pulmonologists were included in the study if they were actively involved in the management and systemic treatment of patients with EGFR-WT mNSCLC and had a clinical workload of at least five patients with EGFR-WT mNSCLC (recurrent or de novo) diagnosed between March 2020 (a date where all five European countries were in lockdown due to COVID-19) up to when data collection ended (August 2021), and at least five patients with EGFR-WT mNSCLC diagnosed in the six months prior to March 2020. 2021;11:635007. Cancer.Net. IntroductionStage III non-small cell lung cancer (NSCLC) is a heterogeneous disease requiring multimodal treatment approaches. Data collection was undertaken in line with European Pharmaceutical Marketing Research Association guidelines and as such it did not require ethics committee approval. In a Dutch survey, 30% of 2664 patients with cancer reported consequences for their oncological management, of which conversion from hospital visit to consultation by phone or video was most frequently reported [44]. Among the total EGFR-WT/ALK-WT mNSCLC population (n=1073), advanced treatment was mostly chemotherapy only (39.2%) followed by immune-oncology monotherapy (IO; 35.0%) (Table 3). 2020;5:2381468320922208. EuroQol Group. World Health Organization. The DSP uses survey techniques to collect anonymized data that is analyzed in aggregated form. 2020;158(1):40615. Provided by the Springer Nature SharedIt content-sharing initiative. Dana-Farber Cancer Institute - Cancer Treatment and Research in Boston, MA The UK was particularly affected in terms of consultations, tests/investigations, and prescribed treatment changes, while the impact on patients in Germany appeared to be relatively low. PD-L150% is a reimbursement criterium in prescribing IO (pembrolizumab) for a number of markets [35], and therefore would play a significant role in informing 1L treatment. At Dana-Farber, you not only get a cancer specialist, but you also get a specialist in your particular type of cancer. J Clin Oncol. Clin Lung Cancer. Tabb F, Reale ML, Bironzo P, Scagliotti GV. tumor ablation therapy, radiofrequency ablation lung metastases . Brucker PS, Yost K, Cashy J, Webster K, Cella D. General population and cancer patient norms for the Functional Assessment of Cancer Therapy-General (FACT-G). Cancer stat facts: lung and bronchus cancer. Immunotherapy was prescribed as 1L NSCLC treatment during COVID-19 for 64.2% (n=786) of patients and pre-COVID-19, for 47.8% (n=549). Some small stage 0 cancers can be treated by endoscopic resection. Accessed 21 Feb 2023. Passaro A, Bestvina C, Velez M, Garassino MC, Garon E, Peters S. Severity of COVID-19 in patients with lung cancer: evidence and challenges. 2016;9:37180. Immunotherapy. PD-L1 status at mNSCLC diagnosis was established in 2239 (94.9%) of 2373 patients, and of these 2239 patients who had their PD-L1 expression level determined, 19.7% had an expression<1%, 46.4% had an expression level of 1%-49% and 34% had an expression level of50%. Methodist Dallas Medical Center offers North Texans a trusted resource close to home for world-class cancer care. Physician and patient data were pseudo-anonymized. Please note that some translations using Google Translate may not be accurately represented and downloaded documents cannot be translated. Figure 3. Patients participating in the surveys may not reflect the general mNSCLC population, as patients who visit more frequently may be more severely affected, require more monitoring, treatment adjustments, or have more emergency visits than those who do not consult their physician as frequently. The Best Prostate Cancer Treatment in the World: 2021 Published by Ronak Bhatiya Last Updated: March 22, 2023 Despite all the medical advances, cancer is still one of the most common causes of death. 2020;21(3):255-63.e4. Patient selection and sample sizes are shown in Fig. Radical surgery remains a treatment mainstay for cancer; however, many patients are not candidates for surgery due to comorbidities, or tumour size,or because they refuse . The majority of these patients (55.6%) had adenocarcinoma. Selecting the optimal immunotherapy regimen in driver-negative metastatic NSCLC. Few changes were made to prescribed treatments during COVID-19 but there was a small shift towards use of 1L immunotherapy potentially as a result of the changing therapeutic landscape. PubMed Lung Cancer Treatment - MD Anderson Cancer Center Indirect comparison with clinical trial data showed that global QoL scores were worse than those 1L single-agent IO, alongside higher than expected symptom burden [39]. The Jimmy Fund supports Dana-Farber, raising funds to help cancer patients and their families around the world. Dr Gangan Gautam, vice chairman-Uro Oncology and Robotic . Indeed, one country - Egypt, which had one of the highest rates of hepatitis C in the world - has already eradicated the disease, which can also lead to liver cancer, liver failure and death. Patient characteristics for the total mNSCLC sample who were EGFR-WT/ALK-WT (n=1073) are shown in (Table 1). We offer a wide range of services, from financial planning to creative arts to spiritual care and more, to support our patients through their cancer experiences. Brahmer JR, Rodrguez-Abreu D, Robinson AG, Hui R, Csszi T, Flp A, et al. The discovery of targetable mutations in genes other than EGFR and ALK, such as c-ros oncogene 1 (ROS1) and v-Raf murine sarcoma viral oncogene homolog B (BRAF) has led to the development of additional targeted therapies in NSCLC, specific to each genomic mutation [11]. As such, immunotherapy has mainly been continued, but with the use of longer cycle options where available, and chemotherapy-based regimens have been used only when necessary [43]. IRVINE, Calif. July 27, 2022 City of Hope, one of the largest cancer research and treatment organizations in the United States, opens its visionary comprehensive cancer center in Orange County, California, creating a national model for delivering breakthrough research and pioneering treatments.
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