Chen, X., Song, M., Zhang, B., and Zhang, Y. Cell. J. Physiol. R, The efficiency of zeolite's ability to remove urea,p-cresol, and creatinine, may be more effective than conventional dialysis. doi: 10.1016/j.micromeso.2004.10.039, Gulam, W., and Ahsan, H. (2006). Federico, A., Dallio, M., Gravina, A. G., Iannotta, C., Romano, M., Rossetti, G., et al. 5, 4758. This veterinary application showed that mineral levels in the blood were not affected by clinoptilolite supplementation which may be relevant for human applications as well. Despite its extensive . (2013). Dietary supplementation with an activated zeolite clinoptilolite in immunodeficiency: effects on the immune system. (2015). This immunostimulation occurs upon simultaneous interaction of the superantigen with MHC class II molecules and T-cell receptors. (2005). Even though the efficacy and potential of clinoptilolite materials in medicine seems high, questions have been raised on to possible clinoptilolite effects on physiologically relevant elements, i.e., micronutrients and trace elements, or effects on important processes in the organism. Lennicke, C., Rahn, J., Lichtenfels, R. A., Wessjohann, L. A., and Seliger, B. doi: 10.1201/b18211, Inoue, M., Sato, E. F., Nishikawa, M., Park, A. M., Kira, Y., Imada, I., et al. This is why antibiotics are standardly used in poultry meat production. It is a principal method for preparation of certain zeolites such as CHA-type materials [3, 4]. doi: 10.1023/B:MCBI.0000049134.69131.89, Valpoti, H., Graer, D., Turk, R., urii, D., Vince, S., Folnoi, I., et al. Clay Miner. 57, 69256935. R, INF was increasingly induced only by talc in MMDM and by sepiolite NC and talc in HMDM, but not by clinoptilolite NC. Longev. In case of antioxidant enzymes, these co-factors may include the coenzyme Q10, vitamins B1 and B2, carnitine, selenium, and often transition metals Cu, Mn, Fe, and Zn (Khalid, 2007). J. Environ. doi: 10.1007/s40279-014-0153-2, Ortatatli, M., and Ouz, H. (2001). Nutr. 278, 553558. Clay quartz mordeniteheulandite epistilbite stilbite thomsonitemesolite-scolecite chabazite calcite. Insights into colonic protein fermentation, its modulation and potential health implications. The single layer of the intestinal epithelium is protected by mucus containing mucin glycoproteins where immunoglobulin A (IgA) and antimicrobial peptides prevent interaction of microbiota with the cell surface. As clinoptilolite particles are negatively-charged polyanions, they might also target cancer cells and induce additional oxidative stress upon entrance into the cytoplasm through hydrogen peroxide activation, increased production of ROS and its consequent depletion within the cell. Medical applications of zeolites, in Handbook of Zeolites Science and Technology, eds S. M. Auerbach, A. Kathleen, K. A. Carrado, and P. K. Dutta (New York, NY: CRC Press), 11431173. Lactic acid bacteria improves Peyers patch cell-mediated Immunoglobulin A and tight-junction expression in a destructed gut microbial environment. In this paper, the cited literature on clinoptilolite effects in vitro and in vivo provides data for clinoptilolite materials (tuffs) from different sources/continents, of different purity, chemical composition, and that were prepared for oral application by use of different milling processing methods. Biological effects and toxicology data should therefore be carefully evaluated according to the type of clinoptilolite material or clinoptilolite-based preparations used in a particular study or application. Studies on free radicals, antioxidants, and co-factors. (2004). Advertisement What is it? It can therefore be utilized as an adjuvant in anticancer therapy. Interestingly, the supplementation with Panaceo Sport positively influenced the intestinal wall integrity, which was witnessed through decreased concentrations of the tight junction modulator zonulin, a marker of increased intestinal permeability (Lamprecht et al., 2015). Their molecular structure is a dense network of AlO4 and SiO4 that generates cavities where water and other polar molecules or ions are inserted/exchanged. 4, 255259. Interv. In line with these results, it should also be hypothesized that clinoptilolite might have the potential to combat acute fluoride-intoxication in animals, as well as in humans. 6, 186199. If this sounds too good to be true because youve tried everything think again. Anticancer Res. Besides metal cations and water resident in zeolites cavities and pores, other molecules and cationic groups may be accommodated as well, such as, for instance, ammonia, and nitrate ions, all of which are bound to different zeolites at different affinity levels (Gaikwad and Warade, 2014). Effects of dietary inclusion of a zeolite (Clinoptilolite) on performance and protein metabolism of young growing pigs. The widely tested zeolite suitable for medical applications in vivo is the clinoptilolite tuff but the mordenite tuff was also studied by Selvam et al. Int. A Brief Comment on the Effect of Natural Clinoptilolite Zeolite in the Human Body, Information Material for Doctors, Naturopaths, Therapists, Pharmacists, Chemists, and Scientists. doi: 10.4014/jmb.1512.12002, Svoboda, D. L., and ulcov, A. P. (2008). doi: 10.1016/j.rvsc.2015.07.014. A variety of highly positive effects on animal and human health were documented thus far for clinoptilolite-based materials. Theyll even refund your money if youre not happy with the product, less return shipping of course. Peroxiredoxin 1 - an antioxidant enzyme in cancer. Berlin: Schibri-Verlag. in Principles of Mucosal Immunology, eds P. D. Smith, T. T. MacDonald, and R. S. Blumberg (New York, NY: Garland Science). (2016). Clin. S. J. T. Gowder (Rijeka: InTech). Other routes and factors may induce ROS in the organism as well, such as ROS produced through the activity of xanthine oxidase, in reactions of hypoxanthine to xanthine and xanthine to uric acid conversions, where molecular oxygen is reduced to superoxide anion, followed by a generation of hydrogen peroxide (Valko et al., 2004). *Correspondence: Sandra Kraljevi Paveli, sandrakp@biotech.uniri.hr, Chemical Properties and Biological Application of Natural Zeolite Clinoptilolite, Use of Clinoptilolite in Veterinary and Human Medicine, Zeolites Effects on Oxidative Stress and Immune System, Clinoptilolite Toxicology in Animals and Humans, http://www.chemtube3d.com/solidstate/SS-Z-Clinoptilolite.htm, http://europe.iza-structure.org/IZA-SC/ftc_table.php, Morillas-Ruiz and Hernndez-Snchez, 2015, EFSA Panel on Additives and Products or Substances used in Animal Feed, 2013, Creative Commons Attribution License (CC BY). The Zeolite Clinoptilolite can bind to toxins throughout the whole body and has an affinity for toxins only, so it never removes beneficial minerals, and there are no negative side effects. (2015). Biol. Sci. Rep. 11, 99104. Cell. Front. doi: 10.3233/JAD-2012-121231, Demir, A., Gnay, A., and Debik, E. (2002). I have listed out 12 benefits of a zeolite detox from removing heavy metals to easing hangovers! Moreover, clinoptilolite incorporated into the diet may be effective in fighting mycotoxins by direct absorption. 33, 423430. R, For example, Polycyclic Aromatic Hydrocarbons (PAHs) are generated from smoking foods and zeolite filters may help reduce PAHs from the food while retaining the flavor. In this preclinical toxicology study, tribomechanically micronized clinoptilolite was evaluated at the Ruer Bokovi Institute in Zagreb, Croatia, according to the standards and regulations required at the time by the OECD. doi: 10.1180/claymin.2011.046.2.295, Covarrubias, L. (2008). Safety of the material was also proven by Ivkovic et al. For instance, regular moderate exercise increases the resistance against oxidative stress, while acute and vigorous exercise can generate free radicals in excess. Rev. Cell. Effect of long-term dietary supplementation with clinoptilolite on performance and selected serum biochemical values in dairy goats. Some concerns were raised in public on the possible lead leakage from the natural clinoptilolite materials into the intestine. Technol. Lipids Health Dis. Silicic acid in drinking water prevents age-related alterations in the endothelium-dependent vascular relaxation modulating eNOS and AQP1 expression in experimental mice: an immunohistochemical study. Also, in chicken, daily supplementation with a natural clinoptilolite, or a modified clinoptilolite, efficiently improved the antioxidant capacity by increasing the antioxidant enzyme activities in intestine mucosa and decreasing the free radical NO content and inducible nitric oxide synthase activity in the serum. Hughes, R., and Magee, E. A. R, The sequence of silica-rich volcanic rocks commonly progresses from. Sci. but also by the material composition and cation affinity properties. . doi: 10.1016/j.ydbio.2008.04.041, Cutovic, M., Lazovic, M., Vukovic-Dejanovic, V., Nikolic, D., Petronic-Markovic, I., and Cirovic, D. (2017). doi: 10.1080/01496399008050409. doi: 10.2147/CEG.S81929. Therefore, the up and down test on mice was performed with doses ranging from 60 to 400 mg/mice/day. Large amounts of research have been done on all the possible benefits of detoxing with Zeolite and studies show that they appear to balance pH within the body, reduce allergies, act as antioxidants, and aid liver function [ 1]. Removal of nitrate from groundwater by using natural zeolite of Nizarneshwar Hills of Western India. Lab. Immunology 82, 332335. Curr. Rare Miracle Mineral Removes Deadly Toxins & Heavy Metals, Zeolite Clinoptilolite: The Miracle Mineral for Detox, Warning: Most Zeolite Products Do Not Work, Most Effective Zeolite on the Market (Backed by Science), What People Say About Pure Body Extra Strength. Sci. doi: 10.1016/S0169-1317(03)00095-4. In-field evaluation of clinoptilolite feeding efficacy on the reduction of milk aflatoxin M1 concentration in dairy cattle. From this perspective, clinoptilolite was evaluated in a recent trial performed on aerobically trained subjects (Lamprecht et al., 2015). La roca magica: uses of natural zeolites in agriculture and industry. Oral consumption of this type of zeolite, due to its extreme chemical stability, in EFSAs opinion, does not represent a potential risk for in vivo applications (EFSA Panel on Additives and Products or Substances used in Animal Feed, 2013). J. Biomed. Med. FEMS Microbiol. 20, 201207. . R, Bacteriophage MS2 - can infect E. Coli R R, Zeolite can stop the growth of certain parasites such as Entamoeba histolytica. Evidence was provided on the role of cross-talking between the adaptive immune system and gut microbiota by selective generation of immune responses to bacteria that consequently stimulate the innate system and production of IgA. clinoptilolite (TMAZ) or furthermore as double tribomechanically activated zeolite clinoptilolite (PMAZC) allows improving its benefits in preclinical and clinical models. Paveli, K., oli, M., and Suboti, B. doi: 10.1016/S0024-3205(03)00567-8, Mumpton, F. A. R, It can increase levels of Lactobacillusspp. Med. You may submit a support ticket, ask questions, or simply leave a comment. Mater. Front. R, Inhaling zeolite can be dangerous to the lungs. doi: 10.1186/1743-7075-10-2, Katic, M., Bosnjak, B., Gall-Troselj, K., Dikic, I., and Pavelic, K. (2006). Preventive effects of zeolite in swerer-rat intoxication with Vx-Substance. Proc. Superoxide ion: generation and chemical Implications. (2005a), for instance, showed that the clinoptilolite supplementation reduced its incidence and did not affect serum concentrations of total calcium, phosphate, magnesium, potassium, and sodium. FIGURE 3. Rep. 6:30913. doi: 10.1038/srep30913, Beltcheva, M., Metcheva, R., Popov, N., Teodorova, S. E., Heredia-Rojas, J. For instance, in long-term supplementation with clinoptilolite, a decreased prevalence of E. coli carrying certain antimicrobial resistance and virulence genes was documented (Jahanbakhsh et al., 2015). Claims that zeolite can help the body fight cancer (supposedly by removing cancer-causing substances in the stomach) have not been substantiated in human studies. But nature does. Activation may be performed either through chemical treatment, e.g., with an acid, by replacing stabilizing cations, or through mechanical modifications by means of different micronization methods, which may all increase the surface area and change the ion-exchange properties and adsorption capacity (Abdulkerim, 2012; Akimkhan, 2012; Canli et al., 2013b). 392, 141154. We were so impressed that we reached out to the company about making this zeolite available to our readers. Indeed, the microbiota-clinoptilolite interaction may also underlie the observed immunomodulatory mechanism as well. Also, it cannot be ruled out that some clinoptilolite particles enter into tumor cells in vitro, as tumor cells are inherently depolarized (Yang and Brackenbury, 2013) and can uptake particles by endocytosis (Sincai et al., 2007). But to take out heavy metals and other toxins, the zeolite must also be cleansed and pre-filled with alkalizing minerals. Benefits from zeolite application could translate to increased yield, more efficient use of nutrient inputs, and reduction in environmental pollution of nitrogen (N) and phosphorus (P) in bodies of water, as well as reduction in greenhouse gas emissions (Fig. For instance, clinoptilolite has been tested as a possible supplementation to broilers feed as an alternative to antibiotics for: (1) the control of the total flora at broiler farms, where clinoptilolite supplementation showed a positive effect on the total flora, a parameter often used in the evaluation of the gastrointestinal health status in poultry (Mallek et al., 2012), as well as on the performance of production and organoleptic parameters, especially on the increase of omega-3 fatty acid levels in eggs (Mallek et al., 2012); (2) the improvement of the antioxidant capacity in broilers where the supplementation of clinoptilolite materials increased the activities of glutathione peroxidase, catalase, total SOD, and the total antioxidant capacity (Wu Y. et al., 2013); (3) the reduction of mycotoxin effects on broilers health, where the number of aflatoxin-affected broilers, or the number of severe lesions in the liver of chickens, was reduced in the clinoptilolite-supplemented group (Ortatatli and Ouz, 2001). This is why definite conclusions on eventual lead fate in the blood and organism of animals fed with clinoptilolite supplemented diet in this study cannot, be conclusive. Cell Host Microbe 2, 328339. The Benefits of Zeolite - Agent Nateur Observed clinically relevant effects on organs and systems for different clinoptilolite materials in vivo are due to major clinoptilolite properties: detoxification, antioxidant effect, release of trace elements, and positive influence on the microbiota status in the intestine as described in Table 1. It commonly occurs as a devitrification product of volcanic . R, For example in humans, zeolite can improve tight junction function and normalize Zonulin (ZO-1) and Interleukin 10 (IL-10) levels. R, Lead-induced Attention Deficit Hyperactivity Disorder (ADHD)may be able to be counteracted by zeolite. Environ. Mineralogy and Acid Neutralisation Mechanisms in Inland Acid Sulfate Environments. Kraljevi Paveli, S., Micek, V., Filoevi, A., Gumbarevi, D., urga, P., Bulog, A., et al. Imagine clearer thinking, ease in recalling tasks, improved mood and much more because your brain is now free of neurotoxic heavy metals! Collela also emphasized the variability and heterogeneity of the clinoptilolite material used in different applications and studies and suggested to study in detail the applications and mechanisms of clinoptilolite materials in light of known and well-established properties or behaviors. doi: 10.2460/ajvr.70.3.346. while lowering Enterobacteriaceaespp. Pharmacol. The variety of zeolites application is indeed a consequence of their porous structure: pores form negatively charged channels and cavities, which are occupied with positively charged alkali, and alkali earth monovalent (i.e., Na+, K+), and divalent (i.e., Ca2+) ions, OH-groups or H2O molecules, which can be easily exchanged by other molecules and cations from the surroundings (Figure 2). ASM News 71, 529535. It is important to note that M-cells apical and basolateral sides, which communicate with Peyers patches, are polarized (Society for Mucosal Immunology, 2012) and one may hypothesize that, due to this particular phenotype, M-cells retain clinoptilolite particles or silica particles released from the clinoptilolite material (tuff), which do not enter the blood system (Nizet et al., 2018) and act locally on this tissue. Removal of heavy metal and other cations from wastewater using zeolites, Sep. Sci. R, For example, zeolite 4A inhibited melanin synthesis induced by alpha-melanocyte-stimulating hormone (alpha-MSH) in melanoma cells. (2009). R, It is used in health industry as adsorbent of free radicals, toxic metals and radioactive elements due to exceptional adsorption, catalyst and ion-exchange properties. Exp. We consider all of the above clinoptilolite properties and propose its mechanisms of action in vivo (summarized in Table 1) and propose some comprehensive, scientifically-based hypotheses on possible biological mechanisms underlying observed effects on the health and body homeostasis. 31, 666672. Res. (2002). It can bind to and remove heavy metals, toxins, and other harmful substances from the body. Zeolite Benefits and How to Take Zeolite Powder - Nourishme Organics doi: 10.1081/ESE-200026265. Erythrocyte, hemoglobin, and platelet levels in peripheral blood were not affected by clinoptilolite supplementation either. J. Zeolite the magic stone; main nutritional, environmental, experimental and clinical fields of application. Interdiscip. Because there is one natural mineral that can clear out the toxic garbage thats been holding you back, so you can feel better than you have in years. Handbook of Zeolite Science and Technology. Process. The structure of mineral clays is, for instance, organized in layers (sheets), while clinoptilolite has tetrahedra arranged in a way that they form large amounts of pore space in the crystals. That picture above is of Bella getting her daily dose. Also, previously published results from trials on animals and human subjects showed a strong clinoptilolite detoxifying effect and reduction of Pb content in vivo. New York, NY: CRC Press. What Are the Health Benefits of Zeolite? | Healthfully
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